10. The Caucasian shepherd dog was first bred in the Northern Caucasian area as a guardian dog. So, even though there is no general rule about which dogs are large, here are 25 of the largest dog breeds, which are all seriously big pups. This breed has an average weight of 68-110 kg and shoulder height of 27-33 inches. Largest Dog Breed. Mastiff breeds are certainly among the largest dog breeds in terms of sheer mass. One of the four breeds from the Swiss Alps, the Bernese Mountain Dog is a large sized breed who was used as a farm dog but is currently used as a working dog. If the biggest dog breeds had an award for the fastest-growing puppy, the Irish Wolfhound would be a strong contender. The following breeds of dogs are among the world's largest. No one really knows the “canine recipe” used by Heinrich Essig, but the result was a dog … Here is the list of the biggest dogs in the world. Bernese Mountain Dogs … Stanimir G.Stoev/Shutterstock. At least three big breeds went into the creation of the Leonberger: the Newfoundland, the Saint Bernard and the Great Pyrenees. On 26th September 1981 the Guinness book of world records recognized an old English Mastiff named Zorba as the heaviest and longest dog … Caucasian Shepherd Dog. English Mastiff is the largest dog breed in the world by considering the mass. Bernese Mountain Dog. This breed comes in several colors including black, blue, mahogany and tawny.